منابع مشابه
Oncogenic HMGA2: short or small?
The High Mobility Group A (HMGA) family of proteins are architectural transcription factors that bind to DNA and introduce structural alterations in chromatin. The HMGA family consists of two members, HMGA1 and HMGA2, which are encoded by separate genes. As one of the major nonhistone chromosomal proteins, HMGA proteins are multifunctional and are involved in many fundamental cellular processes...
متن کاملTransactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2.
The gene encoding the architectural transcription factor HMGA2 is frequently rearranged in several benign tumors of mesenchymal origin. The lipoma preferred partner (LPP) gene is the most frequent translocation partner of HMGA2 in a subgroup of lipomas, which are benign tumors of adipose tissue. In these lipomas, HMGA2/LPP fusion transcripts are expressed, which encode for the three AT-hooks of...
متن کاملHMGA2 is a driver of tumor metastasis.
The non-histone chromatin-binding protein HMGA2 is expressed predominantly in the mesenchyme before its differentiation, but it is also expressed in tumors of epithelial origin. Ectopic expression of HMGA2 in epithelial cells induces epithelial-mesenchymal transition (EMT), which has been implicated in the acquisition of metastatic characters in tumor cells. However, little is known about in vi...
متن کاملHMGA2 regulates lung cancer proliferation and metastasis
BACKGROUND This study aimed to explore the effects of HMGA2 on cell proliferation and metastases in lung cancer and its underlying mechanism. METHODS HMGA2 expression in lung cancer tissues and its association with overall survival were analyzed based on data from a public database. The roles of HMGA2 were validated via loss-of-function and gain-of-function experiments in vitro. HMGA2 regulat...
متن کاملHmga2 translocation induced in skin tumorigenesis
Hmga2 protein, a transcription factor involved in chromatin architecture, is expressed chiefly during development, where it has many key biological functions. When expressed in adult tissues from in various organs, Hmga2 is always related to cancer development. The role of Hmga2 in skin tumorigenesis is, however, not yet understood. We demonstrated that Hmga2 can be found in non-transformed epi...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/38225